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Products, accessories, replacement parts, and protection designed for use with desks, tables, workstations, and benches in laboratory, office, and healthcare settings.
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VRT-043198 is a potent, selective, and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. It is the agent metabolite of VX-765 (Belnacasan). This inhibitor exhibits Ki values of 0.8 nM for ICE/caspase-1 and 0.6 nM for caspase-4.
Potent, selective, and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.
Exhibits Ki values of 0.8 nM for ICE/caspase-1 and 0.6 nM for caspase-4.
Exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9.
Inhibits the release of interleukin (IL)-1β and IL-18.
Has little effect on IL-1α, tumor necrosis factor-, IL-6, and IL-8.
Lacks potent antiapoptotic activity.
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